At Metabolic Modeling Services, Ltd., our focus is on computer modeling. We are in the USA & New Zealand.
Meryl E. Wastney-Pentchev, Ph.D.
Director, Metabolic Modeling Services Ltd
PO Box 98, Blenheim
EDUCATION & BACKGROUND
· B. Ag. Sci. (1st Class Honors) Lincoln College, New Zealand, 1976
· Ph.D. (Biochemistry) Lincoln College, New Zealand, 1980
· Postdoc Laboratory of Mathematical Biology, NCI, NIH Bethesda, MD, 1980-1983
· Associate Professor, Departments of Pediatrics and Biomathematics and Biostatistics
Georgetown University Medical Center, Washington DC, 1983-2000
Director, Metabolic Modeling Services Ltd, Blenheim, New Zealand
· Adjunct Professor, Department of Foods and Nutrition, Purdue University
· Adjunct Associate Professor of Biomathematics and Biostatistics, Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine
I am interested in computer modeling of whole body metabolism. Early studies focused on intermediary metabolism (glucose, ketone bodies, and lipoproteins) in humans. Subsequent studies were of zinc metabolism and zinc homeostasis on high zinc intakes, and magnesium metabolism.
The studies used isotopes as tracers and kinetic data have been analyzed by modeling using the WinSAAM (Windows version of the Simulation, Analysis and Modeling) software.
My previous work (200-2006)included leading an interdisciplinary team at Dexcel Research, developing a system model. The purpose of the model is to simulate research trials. Published models for pasture growth and animal metabolism have been linked to climate and management policies for predicting production and animal health.
A related area of interest is the development of a 'model library' for Internet access to published models of biological systems. The library serves as a resource for research and education. I have taught a graduate course on modeling, as well as 3-5 day workshops.
Current projects are: Calcium metabolism in adolescents (Dr. Connie Weaver, Purdue University)
Calcium loss in astronauts (Dr. Scott Smith, JSC, NASA)
Selenium in adults (Dr. B. Patterson, NCI, NIH)
Wastney ME, Wolff JE, Bickerstaffe R, Ramberg CF, and Berman M. Kinetics of glucose metabolism in sheep. Aust J Biol Sci 36: 463-474, 1983.
Wastney ME, Hall SEH, and Berman M. Ketone body kinetics in humans: A mathematical model. J Lipid Res 25: 160-174, 1984.
Hall SEH, Wastney ME, Bolton TM, Braaten JT, and Berman M. Ketone body kinetics in humans: the effects of insulin-dependent diabetes, obesity, and starvation. J Lipid Res. 25: 1184-1194, 1984.
Wastney ME, Aamodt RL, Rumble WF, and Henkin RI. Kinetic analysis of zinc metabolism and its regulation in normal humans. Am J Physiol. 251 (Reg Integr Comp Physiol 20):R398-R408, 1986.
Hensley P, Nardone G, Chirikjian JG, and Wastney ME. The time-resolved kinetics of superhelical DNA cleavage by BamHI restriction endonuclease. J Biol Chem 265: 15300-15307, 1990.
Wastney ME, Ahmed S, and Henkin RI. Changes in regulation of human zinc metabolism with age. Am J Physiol 263 (Reg Integ Comp Physiol 32):R1162-R1168, 1992.
Wastney ME, Broering N, Ramberg CFR, Jr, Zech LA, Canolty N, and Boston RC. World-wide access to computer models of biological systems. Info Serv Use 15:185-191, 1995.
Wastney ME, Ng J, Smith D, Martin BR, Peacock M, and Weaver CM. Differences in calcium kinetics between adolescent girls and young women. Am J Physiol (Regulator, Integrative Comp. Physiol. 40):208-R216, 1996.
Wastney ME, Angelus P, Barnes RM, and Siva Subramanian KN. Zinc kinetics in preterm infants: A compartmental model based on stable isotope data. Am. J. Physiol. 271(Reg. Integ Comp. Physiol. 40) R1452-1459, 1996.
Smith SM, Nyquist LE, Shih C-Y, Wiesmann H, Nillen JL, Wastney ME, and Lane HW. Calcium kinetics using microgram stable isotope doses and saliva sampling. J Mass Spect. 31:1265-1270, 1996.
Wastney ME, Siva Subramanian KN, Broering N, and Boston R. Using models to explore whole body metabolism and accessing models through a model library. Metabolism 46:330-332, 1997.
Sojka J, Wastney M, Abrams S, Lewis SF, Martin B, Weaver C, and Peacock M. Magnesium kinetics in adolescent girls determined using stable isotopes: Effects of high and low calcium intake. Am. J. Physiol. 273 (Regulatory, Integrative and Comparative Physiology 42): R710-R715, 1997.
House WA and Wastney ME. Compartmental analysis of zinc kinetics in mature, male rats. Am. J. Physiol. 273 (Regulatory, Integrative and Comparative Physiology 42): R1117-1125, 1997.
Wastney ME, Wang XQ, and Boston RC. Publishing, interpreting, and accessing models. J. Franklin Inst. Eng. Appl. Math. 335B: 381-301, 1998.
Wastney ME, Yang D, Andretta DF, Blumenthal J, Hylton J, Canolty N, Collins J and Boston RC. Distributing working versions of published mathematical models for biological systems via the Internet. Adv. Exp Med Biol 445: 131-135, 1998
Boston RC, Greif P, Wastney M, and Linares O. Balancing needs, efficiency and functionality in the provision of modeling software: a perspective of the NIH WinSAAM project. Adv. Exp Med Biol 445:3-20, 1998
Hanes DA, Weaver CM, and Wastney ME. Calcium and oxalate kinetics differ in rats. J. Nutr. 129:165-169, 1999.
Hanes DA, Weaver CM, Heaney RP, and Wastney ME. Absorption of calcium oxalate does not require dissociation in rats. J. Nutr. 129, 170-173, 1999.
Wastney ME, Angelus PA, Barnes RM, and Siva Subramanian KN. Zinc absorption, distribution, excretion, and retention by healthy preterm infants. Pediatr. Res. 45:191-196,1999.
Neufeld EB, Wastney M, Patel S, Suresh S, Cooney AM, Dwyer NK, Roff CF, Ohno K, Morris JA, Carstea ED, Incardona, JP, Strauss JF III, Vanier MT, Patterson MC, Brady RO, Pentchev PG, and Blanchette-Mackie, E. The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. J. Biol. Chem. 274:9627-9635, 1999.
Smith SM, Wastney ME, Morukov BV, Larina IM, Nyquist LE, Abrams SA, Taran EN, Chih C-Y, Nillen JL, Davis-Street JE, Rice BL, and Lane HW. Calcium metabolism before, during, and after a 3-month space flight: kinetic and biochemical changes. Am. J. Physiol. (Regulatory, Integrative Comp. Physiol. 46):R1-R10, 1999.
Wastney ME, House WA, Barnes RM, and Siva Subramanian KN. Kinetics of zinc metabolism: Variation with diet, genetics and disease. J. Nutr. 130:1355S-1359S 2000.
Bright KB, Sherlock RA., Lile J, Wastney, ME Development and use of a whole farm model for dairying. In: Applied Complexity - from Neural Nets to Managed Landscapes. Halloy S. and Williams T. NZ Crop & Food Research, 382-389, 2000.
Wastney ME, Martin BR, Peacock M, Smith D, Jiang X-Y, Jackman LA, and Weaver CM. Changes in calcium kinetics in adolescent girls induced by high calcium intake. J Clin Endocrinol Metab 85:4470-4475, 2000.
Wastney ME, Palliser C.C, Lile JA, Macdonald KA, Penno JW and Bright KP. A Whole Farm Model Applied to a Dairy System NZSAP 2002
Wastney ME, Morukov BV, Larina IM, Abrams SA, Nillen JL, Davis-Street JE, Lane HW, and Smith, SM. Modeling calcium loss from bones during space flight. International Congress on Modelling and Simulation Proceedings. Oxley L. Scrimgeour F, and McAleer M. (Eds), Vol 2, The Modeling and Simulation Society of Australia and New Zealand, Inc. 548-552, 1999.
Weaver CM, Wastney M, and Spence, LA. Quantitative clinical nutrition approaches to the study of calcium and bone metabolism. Clin Rev Bone Min Metab 1: 219-232, 2002.
Bryant RJ, Wastney ME, Martin BR, Wood O, McCabe GP, Morshidi M, Smith DL, Peacock M, Weaver CM. Racial differences in bone turnover and calcium metabolism in adolescent females, JCEM 88:1043-1047, 2003
Wastney ME, Martin B, Bryant R, and Weaver CM. Calcium utilization in young women: New insights from modeling. Mathematical Modeling in Nutrition and Health, edited by Novotny JA, Green MH, and Boston RC, by Kluwer Academic/Plenum, NY. Adv Exp Biol Med 537: 193-205, 2003
Wastney ME, Pentchev PG, Neufeld EB. Fitting a mathematical model to biological data: Intracellular trafficking in Niemann-Pick C disease. Mathematical Modeling in Nutrition and Health, edited by Novotny JA, Green MH, and Boston RC, by Kluwer Academic/Plenum, NY. Adv Exp Biol Med 537: 63-75, 2003
Cai J, Zhang Q, Wastney ME and Weaver CM. Calcium bioavailability and kinetics of calcium ascorbate and calcium acetate in rats. Exp Biol Med 229: 40-45, 2004
Zafar TA, Weaver CM, Zhao Y, Martin BR, and Wastney ME. Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovarectomized rats. J Nutr 134:399-402, 2004.
Beukes PC, Thorrold BS, Wastney ME, Palliser CC, Macdonald KA, Bright KP, Lancaster JAS, Palmer CAJ and Auldist MJ. Modelling the bi-peak lactation curves of summer calvers in New Zealand dairy farm systems. Aust. J. Exp Agric 45:643-649 (2005)
Smith SM, Wastney ME, O’Brien KO, Morukov BV, Larina IM, Abrams SA, Davis-Street JE, Oganov V, Shackelford LC. Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the Mir space station. JBMR 20: 208-218, 2005
Spence LA, Lipscomb ER, Cadogan J, Martin B, Wastney ME, Peacock M, Weaver CM.The effect of soy protein and soy isoflavones on calcium metabolism in postmenopausal women: a randomized crossover study. Am J Clin Nutr. 2005 Apr; 81(4):916-22.
Cai DJ, Zhao Y, Glasier J, Cullen D, Barnes S, Turner CH, Wastney M, Weaver CM. Comparative effect of soy protein, soy isoflavones, and 17beta-estradiol on bone metabolism in adult ovariectomized rats.J Bone Miner Res. 2005 May;20(5):828-39.
Zhao Y, Martin BR, Wastney ME, Schollum L, Weaver CM.Acute versus chronic effects of whey proteins on calcium absorption in growing rats. Exp Biol Med (Maywood). 2005 Sep;230 (8):536-42.
Wastney, ME, Palliser CC, Beukes PC, Levy G, and Folkers C. Modeling complex biological systems: The challenges, with examples from human health and agriculture. In: Mathematical Modeling in Nutrition and Agriculture (Hanigan MD, Novotny JA and Marstaller CL, Eds), Virginia Tech, Blacksburg, VA, 2007
Patterson BH, Wastney ME, and Combs, GF Jr. Calculation of the amounts of organic and inorganic selenium in the human diet from kinetic studies In: Mathematical Modeling in Nutrition and Agriculture (Hanigan MD, Novotny JA and Marstaller CL, Eds), Virginia Tech, Blacksburg, VA, 2007
Beukes PC, Palliser CC, Macdonald KA, Lancaster JAS, Levy G, Thorrold BS, Wastney ME Evaluation of a Whole Farm Model for pasture-based dairy systems. J Dairy Sci 91: 2353-2360, 2008
Wastney ME and House WA. Development of a compartmental model of zinc kinetics in mice. J Nutr. 138:2148-55, 2008 Wu L, Martin BR, Braun MM, Wastney ME, McCabe GP, McCabe LD, DiMeglio LA, Peacock M, Weaver C. Calcium requirements and metabolism in Chinese American boys and girls. J Bone Miner Res. 2010 Aug;25(8):1842-9.
Zhao Y, Cheong JM, Lee W, Wastney M, Martin BR, Weaver CM. Tetracycline and calcium kinetics are comparable for estimating bone resorption in rats. J Nutr. 2010 Sep;140(9):1704-9. Epub 2010 Jul 28.
Siva Subramanian KN and Wastney ME. Kinetic Models of Trace Element and Mineral Metabolism during Development. CRC Press, FL, 1995, 416 pp.
Wastney ME, Patterson BH, Linares OA, Greif PC and Boston RC. Investigating Biological Systems using Modeling: Strategies and Software. Academic Press, 1998, 382 pp.